Article
Signal sequences control gating of the protein translocation channel in a substrate-specific manner.
Developmental cell - 1 Feb 2002
Kim Soo Jung, Mitra Devarati, Salerno Jeffrey R, Hegde Ramanujan S
Abstract excerpt
N-terminal signal sequences mediate targeting of nascent chains to the endoplasmic reticulum and facilitate opening of the protein translocation channel to the passage of substrate. We have assessed each of these steps for a diverse set of mammalian signals. While minimal differences were seen in their targeting function, signal sequences displayed a remarkable degree of variation in initiating nascent chain...
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