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Article

Signal sequences specify the targeting route to the endoplasmic reticulum membrane.

The Journal of cell biology - 1 Jul 1996

Ng D T, Brown J D, Walter P

Abstract excerpt

In the yeast Saccharomyces cerevisiae, only a subset of preproteins that are translocated across the ER membrane require the function of the signal recognition particle (SRP), suggesting that an alternative, SRP-independent pathway must exist (Hann, B.C., and P. Walter. 1991. Cell. 67:131-144). We have established that the two targeting pathways function in parallel. Mutant alleles of SEC62 and SEC63 were...

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Source

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Identifiers

PMID: 8707814
DOI: 10.1083/jcb.134.2.269
PMCID: PMC2120870

Genes

SEC62
SEC63

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Signal sequences specify the targeting route to the endoplasmic reticulum membrane.PMID 8707814Read ↗

Sec63p and Kar2p are required for the translocation of SRP-dependent precursors into the yeast endoplasmic reticulum in vivo.Semantic proximity Read ↗

Sec62 protein mediates membrane insertion and orientation of moderately hydrophobic signal anchor proteins in the endoplasmic reticulum (ER).Semantic proximity Read ↗

Mutants in three novel complementation groups inhibit membrane protein insertion into and soluble protein translocation across the endoplasmic reticulum membrane of Saccharomyces cerevisiae.Semantic proximity Read ↗

The signal recognition particle in S. cerevisiae.Semantic proximity Read ↗

Targeting and translocation of proteins to the endoplasmic reticulum at a glanceSemantic proximity Read ↗

Signal sequences control gating of the protein translocation channel in a substrate-specific manner.Semantic proximity Read ↗

The Brl domain in Sec63p is required for assembly of functional endoplasmic reticulum translocons.Semantic proximity Read ↗

Distinct domains within yeast Sec61p involved in post-translational translocation and protein dislocation.Semantic proximity Read ↗

Signal recognition particle receptor is important for cell growth and protein secretion in Saccharomyces cerevisiae.Semantic proximity Read ↗

Structural and functional dissection of Sec62p, a membrane-bound component of the yeast endoplasmic reticulum protein import machinery.Semantic proximity Read ↗

Sec61p serves multiple roles in secretory precursor binding and translocation into the endoplasmic reticulum membrane.Semantic proximity Read ↗

A new targeting motif for endoplasmic reticulum surface proteinsSemantic proximity Read ↗

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