Article
An iron-regulated sortase anchors a class of surface protein during Staphylococcus aureus pathogenesis.
Proceedings of the National Academy of Sciences of the United States of America - 19 Feb 2002
Mazmanian Sarkis K, Ton-That Hung, Su Kenneth, Schneewind Olaf
Abstract excerpt
Sortase (SrtA), an enzyme that anchors surface proteins to the cell wall of Gram-positive bacteria, cleaves sorting signals at the LPXTG motif. We have identified a second sortase (SrtB) in the Gram-positive pathogen Staphylococcus aureus that is required for anchoring of a surface protein with a NPQTN motif. Purified SrtB cleaves NPQTN-bearing peptides in vitro, and a srtB mutant is defective in the persistence...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.