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Article

Differential recognition of surface proteins in Streptococcus pyogenes by two sortase gene homologs.

Journal of bacteriology - 1 Apr 2002

Barnett Timothy C, Scott June R

Abstract excerpt

The interaction of Streptococcus pyogenes (group A streptococcus [GAS]) with its human host requires several surface proteins. In this study, we isolated mutations in a gene required for the surface localization of protein F by transposon mutagenesis of the M6 strain JRS4. This gene (srtA) encodes a protein homologous to Staphylococcus aureus sortase, which covalently links proteins containing an LPXTG motif to...

Topics

Amino Acid Sequence
Aminoacyltransferases
Bacterial Proteins
Cell Wall
Cysteine Endopeptidases
DNA Transposable Elements
Molecular Sequence Data
Mutation
Streptococcus pyogenes

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Identifiers

PMID: 11914350
DOI: 10.1128/JB.184.8.2181-2191.2002
PMCID: PMC134975

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