Article
Inactivation of the <i>srtA</i> gene in <i>Listeria monocytogenes</i> inhibits anchoring of surface proteins and affects virulence
1 Feb 2002
Abstract excerpt
During infection of their hosts, Gram-positive bacteria express surface proteins that serve multiple biological functions. Surface proteins harbouring a C-terminal sorting signal with an LPXTG motif are covalently linked to the cell wall peptidoglycan by a transamidase named sortase. Two genes encoding putative sortases, termed srtA and srtB, were identified in the genome of the intracellular pathogenic bacterium...
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