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<i>Staphylococcus aureus</i> Sortase, an Enzyme that Anchors Surface Proteins to the Cell Wall

30 Jul 1999

Abstract excerpt

Surface proteins of Gram-positive bacteria are linked to the bacterial cell wall by a mechanism that involves cleavage of a conserved Leu-Pro-X-Thr-Gly (LPXTG) motif and that occurs during assembly of the peptidoglycan cell wall. A Staphylococcus aureus mutant defective in the anchoring of surface proteins was isolated and shown to carry a mutation in the srtA gene. Overexpression of srtA increased the rate of...

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PMID: 10427003
DOI: 10.1126/science.285.5428.760

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Related research

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Research trail→

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<i>Staphylococcus aureus</i> Sortase, an Enzyme that Anchors Surface Proteins to the Cell WallPMID 10427003Read ↗

Inactivation of the <i>srtA</i> Gene in <i>Streptococcus gordonii</i> Inhibits Cell Wall Anchoring of Surface Proteins and Decreases In Vitro and In Vivo AdhesionSemantic proximity Read ↗

Sortases, Surface Proteins, and Their Roles in Staphylococcus aureus Disease and Vaccine DevelopmentSemantic proximity Read ↗

Characterization of <i>Streptococcus suis</i> Genes Encoding Proteins Homologous to Sortase of Gram-Positive BacteriaSemantic proximity Read ↗

Inactivation of the <i>srtA</i> gene in <i>Listeria monocytogenes</i> inhibits anchoring of surface proteins and affects virulenceSemantic proximity Read ↗

Partially overlapping substrate specificities of staphylococcal group A sortases.Semantic proximity Read ↗

An iron-regulated sortase anchors a class of surface protein during Staphylococcus aureus pathogenesis.Semantic proximity Read ↗

Sortases and the Art of Anchoring Proteins to the Envelopes of Gram-Positive BacteriaSemantic proximity Read ↗

Structure and function of a Clostridium difficile sortase enzyme.Semantic proximity Read ↗

The divergent roles of sortase in the biology of Gram-positive bacteriaSemantic proximity Read ↗

A Novel Sortase, SrtC2, from Streptococcus pyogenes Anchors a Surface Protein Containing a QVPTGV Motif to the Cell WallSemantic proximity Read ↗

The Sortase SrtA of Listeria monocytogenes Is Involved in Processing of Internalin and in VirulenceSemantic proximity Read ↗

The SrtA Sortase of Streptococcus agalactiae Is Required for Cell Wall Anchoring of Proteins Containing the LPXTG Motif, for Adhesion to Epithelial Cells, and for Colonization of the Mouse IntestineSemantic proximity Read ↗

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