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Article

Structure and function of a Clostridium difficile sortase enzyme.

Scientific reports - 24 Mar 2015

Chambers Christopher J, Roberts April K, Shone Clifford C, Acharya K Ravi

Abstract excerpt

Sortase enzymes are responsible for covalent anchoring of specific proteins to the peptidoglycan of the cell wall of gram-positive bacteria. In some gram-positive bacteria (e.g. Staphylococcus aureus), sortases have been found to be essential for pathogenesis and their inhibitors are under development as potential novel therapeutics. Here we provide the first report on the structural characterisation of the C....

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Identifiers

PMID: 25801974
DOI: 10.1038/srep09449
PMCID: PMC4371152

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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