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Article

Analysis of the substrate specificity of the Staphylococcus aureus sortase transpeptidase SrtA.

Biochemistry - 17 Feb 2004

Kruger Ryan G, Otvos Balint, Frankel Brenda A, Bentley Matthew, Dostal Patrick, McCafferty Dewey G

Abstract excerpt

The Staphylococcus aureus sortase transpeptidase SrtA isoform is responsible for the covalent attachment of virulence and colonization-associated proteins to the bacterial peptidoglycan. SrtA utilizes two substrates, undecaprenol-pyrophosphoryl-MurNAc(GlcNAc)-Ala-D-isoGlu-Lys(epsilon-Gly(5))-D-Ala-D-Ala (branched Lipid II) and secreted proteins containing a highly conserved C-terminal LPXTG sequence. SrtA...

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PMID: 14769030
DOI: 10.1021/bi035920j

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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