Article
G1 arrest and high expression of cyclin kinase and apoptosis inhibitors in accumulated activated/memory phenotype CD4+ cells of older lupus mice.
European journal of immunology - 1 Aug 1997
Sabzevari H, Propp S, Kono D H, Theofilopoulos A N
Abstract excerpt
A general characteristic of lupus-prone mice (and humans) is the expedited accumulation of large numbers of presumably self-reactive activated/memory phenotype T cells. The mechanism by which these cells escape apoptosis has not been defined. We used activated/memory phenotype CD4+ cells from mal...
Topics
- Aging
- Animals
- Apoptosis
- Autoimmunity
- CD4-Positive T-Lymphocytes
- Cyclin-Dependent Kinases
- Enzyme Inhibitors
- Female
- G1 Phase
- Gene Expression
- Humans
- Hyaluronan Receptors
- Immunologic Memory
- In Vitro Techniques
- Lupus Erythematosus, Systemic
- Lymphocyte Activation
- Male
- Mice