Aging affects the regeneration of the CD8+ T cell compartment in bone marrow transplanted mice.

doi:10.1016/s0047-6374(99)00078-0

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Article

Aging affects the regeneration of the CD8+ T cell compartment in bone marrow transplanted mice.

Mechanisms of ageing and development - 3 Jan 2000

Mu X Y, Thoman M L

Abstract excerpt

A chimeric mouse model has been used to determine the effect of aging on the differentiation of CD8+ T cells and on the regeneration capacity of the mature peripheral T cell pool after radiation induced depletion. Bone marrow cells from Thy 1.1+ mice were transplanted into lethally irradiated young or aged mice (Thy 1.2+). After 6 weeks, splenic CD8+ T cells were subjected to phenotypic and functional...

Topics

Aging
Animals
Animals, Newborn
Bone Marrow Cells
Bone Marrow Transplantation
CD8-Positive T-Lymphocytes
Cell Differentiation
Chimera
Cytokines
Female
Mice
Mice, Inbred C57BL
Mice, Inbred Strains
Phenotype
Regeneration

Source

Open in PubMed

Identifiers

PMID: 10690924
DOI: 10.1016/s0047-6374(99)00078-0

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