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The impact of aging on memory T cell phenotype and function in the human bone marrow

19 Oct 2011

Abstract excerpt

Recently, the BM has been shown to play a key role in regulating the survival and function of memory T cells. However, the impact of aging on these processes has not yet been studied. We demonstrate that the number of CD4⁺ and CD8⁺ T cells in the BM is maintained during aging. However, the composition of the T cell pool in the aged BM is altered with a decline of naïve and an increase in T(EM) cells. In contrast...

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PMID: 22013229
DOI: 10.1189/jlb.0611299

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