Prevention of mis-aminoacylation of a dual-specificity aminoacyl-tRNA synthetase.

doi:10.1006/jmbi.2001.5297

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Article

Prevention of mis-aminoacylation of a dual-specificity aminoacyl-tRNA synthetase.

Journal of molecular biology - 1 Feb 2002

Lipman Richard S A, Wang Jinling, Sowers Kevin R, Hou Ya-Ming

Abstract excerpt

Accurate aminoacylation of tRNAs by aminoacyl-tRNA synthetase is essential for the fidelity of protein synthesis. For Methanococcus jannaschii tRNA(Pro), accuracy is difficult because the cognate prolyl-tRNA synthetase also recognizes and aminoacylates tRNA(Cys) with cysteine. We show here that the unmodified transcript of M. jannaschii tRNA(Pro) is indeed mis-acylated with cysteine. However, the origin of...

Topics

Acylation
Adenosine Triphosphate
Amino Acyl-tRNA Synthetases
Anticodon
Base Sequence
Binding Sites
Cysteine
Genetic Engineering
Kinetics
Methanococcus
Molecular Sequence Data
Mutation
Nucleic Acid Conformation
Proline
RNA Editing
RNA, Transfer, Cys
RNA, Transfer, Pro
Substrate Specificity

Source

Open in PubMed

Identifiers

PMID: 11827467
DOI: 10.1006/jmbi.2001.5297

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