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Article

Prevention of mis-aminoacylation of a dual-specificity aminoacyl-tRNA synthetase.

Journal of molecular biology - 1 Feb 2002

Lipman Richard S A, Wang Jinling, Sowers Kevin R, Hou Ya-Ming

Abstract excerpt

Accurate aminoacylation of tRNAs by aminoacyl-tRNA synthetase is essential for the fidelity of protein synthesis. For Methanococcus jannaschii tRNA(Pro), accuracy is difficult because the cognate prolyl-tRNA synthetase also recognizes and aminoacylates tRNA(Cys) with cysteine. We show here that the unmodified transcript of M. jannaschii tRNA(Pro) is indeed mis-acylated with cysteine. However, the origin of...

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Source

Identifiers

PMID: 11827467
DOI: 10.1006/jmbi.2001.5297

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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