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Article

Structural basis for tRNA-dependent cysteine biosynthesis.

Nature communications - 15 Nov 2017

Chen Meirong, Kato Koji, Kubo Yume, Tanaka Yoshikazu, Liu Yuchen, Long Feng, Whitman William B, Lill Pascal, Gatsogiannis Christos, Raunser Stefan, Shimizu Nobutaka, Shinoda Akira, Nakamura Akiyoshi, Tanaka Isao, Yao Min

Abstract excerpt

Cysteine can be synthesized by tRNA-dependent mechanism using a two-step indirect pathway, where O-phosphoseryl-tRNA synthetase (SepRS) catalyzes the ligation of a mismatching O-phosphoserine (Sep) to tRNACys followed by the conversion of tRNA-bounded Sep into cysteine by Sep-tRNA:Cys-tRNA synthase (SepCysS). In ancestral methanogens, a third protein SepCysE forms a bridge between the two enzymes to create a...

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Identifiers

PMID: 29142195
DOI: 10.1038/s41467-017-01543-y
PMCID: PMC5688128

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