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Article

Lymphocyte Transformation by Pim-2 Is Dependent on Nuclear Factor-κB Activation

15 Nov 2004

Abstract excerpt

Pim-2 is a transcriptionally regulated oncogenic kinase that promotes cell survival in response to a wide variety of proliferative signals. Deregulation of Pim-2 expression has been documented in several human malignancies, including leukemia, lymphoma, and multiple myeloma. Here, we show that the ability of Pim-2 to promote survival of cells is dependent on nuclear factor (NF)-kappaB activation. Pim-2 activates...

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PMID: 15548703
DOI: 10.1158/0008-5472.can-04-2284

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