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Article

Linkage analysis conditional on HLA status in a large North American pedigree supports the presence of a multiple sclerosis susceptibility locus on chromosome 12p12.

Human molecular genetics - 1 Feb 2002

Vitale Emilia, Cook Stuart, Sun Rong, Specchia Claudia, Subramanian Kavitha, Rocchi Mariano, Nathanson Douglas, Schwalb Marvin, Devoto Marcella, Rohowsky-Kochan Christine

Abstract excerpt

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system with a probable immune-mediated pathogenesis. Strong evidence supports the hypothesis that MS is determined by genetic and environmental factors, but these factors remain largely undefined. The genetic component is suggested by a higher concordance rate in monozygotic (28%) versus dizygotic (5%) twins as well as...

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PMID: 11823448
DOI: 10.1093/hmg/11.3.295

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Linkage analysis conditional on HLA status in a large North American pedigree supports the presence of a multiple sclerosis susceptibility locus on chromosome 12p12.PMID 11823448Read ↗

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