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An extended genome scan in 442 Canadian multiple sclerosis-affected sibships: a report from the Canadian Collaborative Study Group.

Human molecular genetics - 15 May 2004

Dyment David A, Sadovnick A Dessa, Willer Cristen J, Armstrong Holly, Cader Zameel M, Wiltshire Steven, Kalman Bernadette, Risch Neil, Ebers George C

Abstract excerpt

Multiple sclerosis (MS) is a complex trait with a sibling relative risk (lambda(sibs)) between 18 and 36. We report a multistage genome scan of 552 sibling pairs from 442 families, the largest MS family sample assessed for linkage. The first stage consisted of a genome scan for linkage with 498 microsatellite markers at an average spacing of 7 cM in 219 sibling pairs. The second stage involved further genotyping...

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PMID: 15069025
DOI: 10.1093/hmg/ddh123

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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