Article
alpha-Synuclein interacts with phospholipase D isozymes and inhibits pervanadate-induced phospholipase D activation in human embryonic kidney-293 cells.
The Journal of biological chemistry - 5 Apr 2002
Ahn Bong-Hyun, Rhim Hyangshuk, Kim Shi Yeon, Sung Young-Mo, Lee Mun-Yong, Choi Ju-Youn, Wolozin Benjamin, Chang Jong-Soo, Lee Young Han, Kwon Taeg Kyu, Chung Kwang Chul, Yoon Shin-Hee, Hahn Sang June, Kim Myung-Suk, Jo Yang-Hyeok, Min Do Sik
Abstract excerpt
alpha-Synuclein has been implicated in the pathogenesis of many neurodegenerative diseases, including Parkinson's disease and Alzheimer's disease. Although the function of alpha-synuclein remains largely unknown, recent studies have demonstrated that this protein can interact with phospholipids. To address the role of alpha-synuclein in neurodegenerative disease, we have investigated whether it binds...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.