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Article

alpha-Synuclein modulation of Ca2+ signaling in human neuroblastoma (SH-SY5Y) cells.

Journal of neurochemistry - 1 Dec 2009

Hettiarachchi Nishani T, Parker Andrew, Dallas Mark L, Pennington Kyla, Hung Chao-Chun, Pearson Hugh A, Boyle John P, Robinson Philip, Peers Chris

Abstract excerpt

Parkinson's disease (PD) is characterized in part by the presence of alpha-synuclein (alpha-syn) rich intracellular inclusions (Lewy bodies). Mutations and multiplication of the alpha-synuclein gene (SNCA) are associated with familial PD. Since Ca2+ dyshomeostasis may play an important role in the pathogenesis of PD, we used fluorimetry in fura-2 loaded SH-SY5Y cells to monitor Ca2+ homeostasis in cells stably...

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Source

Identifiers

PMID: 19860837
DOI: 10.1111/j.1471-4159.2009.06411.x

Genes

SNCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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