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Article

High frequency of mitochondrial complex I mutations in Parkinson's disease and aging.

Neurobiology of aging - 1 Jan 2000

Smigrodzki Rafal, Parks Janice, Parker W Davis

Abstract excerpt

Idiopathic Parkinson's disease (PD) involves a systemic loss of activity of complex I of the mitochondrial electron transport chain. This biochemical lesion plays a key pathogenic role. Transfer of PD mitochondrial DNA recapitulates this loss of activity and several other pathogenic features of P...

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Source

Identifiers

PMID: 15465623
DOI: 10.1016/j.neurobiolaging.2004.02.020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15465623-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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