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Article

Mitochondrial DNA analysis in Parkinson's disease

1 Jan 1990

Abstract excerpt

The reduced form of nicotinamide adenine dinucleotide coenzyme Q reductase (complex I) activity has recently been shown to be deficient in the substantia nigra of patients dying with Parkinson's disease. This biochemical defect is identical to that produced by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), which also produces parkinsonism in humans. Complex I comprises 25 polypeptides, seven...

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Identifiers

PMID: 1979656
DOI: 10.1002/mds.870050406

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