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Article

The role of mitochondrial genetics in Parkinson's disease: Long-read sequencing as an emerging method.

Med (New York, N.Y.) - 14 Nov 2025

Tran Ngan Le Kim, van Blitterswijk Marka, Springer Wolfdieter, McLean Pamela J, Martinez-Peña Eddie G, Savica Rodolfo, Ross Owen A

Abstract excerpt

Parkinson's disease (PD) is one of the most devastating neurodegenerative disorders, influenced by a complex interplay of genetic, epigenetic, and environmental factors. Genetic studies and neuropathological evidence suggest that there may be two main forms of early-onset PD driven centrally by either alpha-synuclein aggregation (Lewy bodies) or mitochondrial dysfunction. While numerous studies have utilized...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41086815
DOI: 10.1016/j.medj.2025.100880

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