Article
[Absence of an association between the C825T polymorphism of the G-protein beta 3 subunit and salt-sensitivity in essential arterial hypertension].
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - 1 Jan 2000
González-Núñez D, Giner V, Bragulat E, Coca A, de la Sierra A, Poch E
Abstract excerpt
The genetic functional variant C for T in position 825 of the gene encoding G protein beta 3 subunit, GNB3, has been associated with enhanced G protein activation, cell growth and proliferation. This phenotype is associated with enhanced G protein activation and Na(+)-H+ exchanger activity in cells from hypertensive patients. Salt sensitivity affects approximately 50% of hypertensive patients and constitutes an...
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