Article
[Activity of the sodium-proton exchanger and polymorphism of G-protein beta-3 subunit in patients with essential hypertension].
Annales Academiae Medicae Stetinensis - 1 Jan 2004
Kedzierska Karolina
Abstract excerpt
The aim of the study was to verify the hypothesis that C825T polymorphism of G-protein beta3 subunit is involved in the development of the intermediate phenotype (increased sodium-proton exchanger activity). If true, increased sodium-proton exchange in the proximal tubule would enhance total sodium load and volemia (volumetric component of blood pressure). On the other hand, direct activation of the sodium-proton...
Topics
- Blood Pressure
- Diet, Sodium-Restricted
- Erythrocytes
- Female
- Heterotrimeric GTP-Binding Proteins
- Humans
- Hypertension
- Male
- Polymorphism, Single Nucleotide
- Reference Values
- Sodium Chloride
- Sodium Chloride, Dietary
- Sodium-Hydrogen Exchangers