Article
[Activity of the sodium-proton exchanger and polymorphism of G-protein beta-3 subunit in patients with essential hypertension].
Annales Academiae Medicae Stetinensis - 1 Jan 2004
Kedzierska Karolina
Abstract excerpt
The aim of the study was to verify the hypothesis that C825T polymorphism of G-protein beta3 subunit is involved in the development of the intermediate phenotype (increased sodium-proton exchanger activity). If true, increased sodium-proton exchange in the proximal tubule would enhance total sodium load and volemia (volumetric component of blood pressure). On the other hand, direct activation of the sodium-proton...
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