Article
The 825C/T polymorphism of the G-protein subunit beta3 is not related to hypertension.
Hypertension (Dallas, Tex. : 1979) - 1 May 1999
Brand E, Herrmann S M, Nicaud V, Ruidavets J B, Evans A, Arveiler D, Luc G, Plouin P F, Tiret L, Cambien F
Abstract excerpt
A polymorphism at position 825 (C-->T) of the cDNA that encodes the beta3 subunit (GNB3) of the pertussis toxin-sensitive G protein was recently shown to be associated with human hypertension. To verify this finding and to investigate whether this polymorphism could also be associated with coronary heart disease, we analyzed the GNB3 variant in subjects from 2 previously described studies: Projet d'Etude des...
Topics
- Adult
- Alleles
- Body Mass Index
- Case-Control Studies
- Confidence Intervals
- Coronary Disease
- DNA, Complementary
- Data Interpretation, Statistical
- Female
- GTP-Binding Proteins
- Genes
- Genotype
- Humans
- Hypertension