Article
G-protein beta3 subunit gene (GNB3) polymorphism 825C-->T in patients with hypertensive crisis.
Critical care medicine - 1 Sept 2000
Buchmayer H, Sunder-Plassmann G, Hirschl M M, Kletzmayr J, Woisetschläger C, Laggner A N, Hörl W H, Födinger M
Abstract excerpt
OBJECTIVE: The polymorphism 825C-->T in exon 10 of the gene GNB3 encoding the beta3 subunit of heterotrimeric guanine nucleotide binding regulatory proteins (G-proteins) results in a splicing variant (GNB3-s) in which the nucleotides 498-620 of exon 9 are deleted. The T allele has been shown to be overrepresented in patients with essential hypertension. Because GNB3-s may support the development of severe...
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