Article
G-protein beta3 subunit 825T allele and response to dietary salt in normotensive men.
Journal of hypertension - 1 Jul 2000
Schorr U, Blaschke K, Beige J, Distler A, Sharma A M
Abstract excerpt
BACKGROUND AND AIMS: A functional single-nucleotide variant of the gene encoding the beta3 subunit of heterotrimeric G proteins (Gbeta3 C825T), associated with enhanced G-protein activation and increased activity of the sodium-proton exchanger (NHE1), has been implicated in the development of hypertension. Given the possible involvement of NHE1 in sodium homeostasis, we tested the hypothesis that the Gbeta3 825T...
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