Article
Detection of genetic alterations in the p53 suppressor gene and the K-ras oncogene among different grades of dysplasia in patients with colorectal adenomas.
Cancer - 1 Jan 2002
Hosaka Shigetoshi, Aoki Yuji, Akamatsu Taiji, Nakamura Naoshi, Hosaka Noriko, Kiyosawa Kendo
Abstract excerpt
BACKGROUND: Although it is believed that p53 suppressor gene mutations, compared with mutations in the K-ras oncogene, occur at a later stage of colorectal tumorigenesis, the distribution of these genetic alterations at an early stage remains poorly characterized. METHODS: The authors analyzed the immunoreactivity for p53 protein (p53 protein expression), which reflects the functionally altered p53 gene, and...
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