Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p53 deficiency does not affect the accumulation of point mutations in a transgene target.

Proceedings of the National Academy of Sciences of the United States of America - 29 Aug 1995

Sands A T, Suraokar M B, Sanchez A, Marth J E, Donehower L A, Bradley A

Abstract excerpt

DNA repair is required by organisms to prevent the accumulation of mutations and to maintain the integrity of genetic information. Mammalian cells that have been treated with agents that damage DNA have an increase in p53 levels, a p53-dependent arrest at G1 in the cell cycle, and a p53-dependent apoptotic response. It has been hypothesized that this block in cell cycle progression is necessary to allow time for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Proteins
Share to Cells, Cultured

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Escherichia coli Proteins

Share to Mice, Transgenic

Share to Phenotype

Share to Point Mutation

Share to Sequence Deletion

Source

Open in PubMed Open full text

Identifiers

PMID: 7667322
DOI: 10.1073/pnas.92.18.8517
PMCID: PMC41188

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p53 deficiency does not affect the accumulation of point mutations in a transgene target.PMID 7667322Read ↗

Elevated mutagenesis and decreased DNA repair at a transgene are associated with proliferation but not apoptosis in p53-deficient cells.Semantic proximity Read ↗

A role for p53 in the frequency and mechanism of mutation.Semantic proximity Read ↗

Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 functionSemantic proximity Read ↗

Age-related mutation accumulation at a lacZ reporter locus in normal and tumor tissues of Trp53-deficient mice.Semantic proximity Read ↗

Mutant frequencies and spectra depend on growth state and passage number in cells cultured from transgenic lacZ-plasmid reporter mice.Semantic proximity Read ↗

Comparison of somatic mutation in a transgenic versus host locus.Semantic proximity Read ↗

Spontaneous mutation frequencies and spectra in p53 (+/+) and p53 (-/-) mice: a test of the 'guardian of the genome' hypothesis in the Big Blue transgenic mouse mutation detection system.Semantic proximity Read ↗

p53 wild-type and p53 nullizygous Big Blue transgenic mice have similar frequencies and patterns of observed mutation in liver, spleen and brain.Semantic proximity Read ↗

Li-Fraumeni syndrome: a p53 family affair.Semantic proximity Read ↗

Radiation-induced point mutations, deletions and micronuclei in lacI transgenic mice.Semantic proximity Read ↗

Tumour incidence, spectrum and ploidy in mice with a large deletion in the p53 gene.Semantic proximity Read ↗

Spontaneous mutations in lacI-containing lambda lysogens derived from transgenic mice: the observed patterns differ in liver and spleen.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.