Article
p53 deficiency does not affect the accumulation of point mutations in a transgene target.
Proceedings of the National Academy of Sciences of the United States of America - 29 Aug 1995
Sands A T, Suraokar M B, Sanchez A, Marth J E, Donehower L A, Bradley A
Abstract excerpt
DNA repair is required by organisms to prevent the accumulation of mutations and to maintain the integrity of genetic information. Mammalian cells that have been treated with agents that damage DNA have an increase in p53 levels, a p53-dependent arrest at G1 in the cell cycle, and a p53-dependent...
Topics
- Animals
- Apoptosis
- Bacterial Proteins
- Bacteriophage lambda
- Cells, Cultured
- Escherichia coli Proteins
- Genetic Vectors
- Lac Repressors
- Mice
- Mice, Transgenic
- Phenotype
- Point Mutation
- Repressor Proteins
- Sequence Deletion
- Tumor Suppressor Protein p53