Article
Counting alleles to predict recurrence of early-stage colorectal cancers.
Lancet (London, England) - 19 Jan 2002
Zhou Wei, Goodman Steven N, Galizia Gennaro, Lieto Eva, Ferraraccio Francesca, Pignatelli Carlo, Purdie Colin A, Piris Juan, Morris Robert, Harrison David J, Paty Philip B, Culliford Al, Romans Katharine E, Montgomery Elizabeth A, Choti Michael A, Kinzler Kenneth W, Vogelstein Bert
Abstract excerpt
BACKGROUND: Chromosome imbalances occur in many cancers and represent important biological properties of tumours. However, measurements of such imbalances are difficult. We used a new, quantitative approach to investigate the prognostic value of chromosome imbalances in early-stage colorectal cancers. METHODS: We studied 180 patients with no evidence of lymph-node or distant metastases at the time of surgery. DNA...
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