Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular predictors of survival after adjuvant chemotherapy for colon cancer.

The New England journal of medicine - 19 Apr 2001

Watanabe T, Wu T T, Catalano P J, Ueki T, Satriano R, Haller D G, Benson A B, Hamilton S R

Abstract excerpt

BACKGROUND: Adjuvant chemotherapy improves survival among patients with stage III colon cancer, but no reliable molecular predictors of outcome have been identified. METHODS: We evaluated loss of chromosomal material (also called loss of heterozygosity or allelic loss) from chromosomes 18q, 17p, and 8p; cellular levels of p53 and p21(WAF1/CIP1) proteins; and microsatellite instability as molecular markers. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chemotherapy, Adjuvant
Share to Chromosomes, Human, Pair 17

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 18

Share to Chromosomes, Human, Pair 8

Share to Colonic Neoplasms

Share to Fluorouracil

Share to Randomized Controlled Trials as Topic

Share to Transforming Growth Factor beta

Source

Open in PubMed Open full text

Identifiers

PMID: 11309634
DOI: 10.1056/NEJM200104193441603
PMCID: PMC3584633

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular predictors of survival after adjuvant chemotherapy for colon cancer.PMID 11309634Read ↗

Microsatellite Instability and Loss of Heterozygosity at Chromosomal Location 18q: Prospective Evaluation of Biomarkers for Stages II and III Colon Cancer—A Study of CALGB 9581 and 89803Semantic proximity Read ↗

Prognostic Significance and Molecular Associations of 18q Loss of Heterozygosity: A Cohort Study of Microsatellite Stable Colorectal CancersSemantic proximity Read ↗

Current status of adjuvant chemotherapy for colorectal cancer. Can molecular markers play a role in predicting prognosis?Semantic proximity Read ↗

Confirmation that chromosome 18q allelic loss in colon cancer is a prognostic indicator.Semantic proximity Read ↗

Allelic loss on chromosome 18q as a prognostic marker in stage II colorectal cancer.Semantic proximity Read ↗

Genetic classification of colorectal cancer based on chromosomal loss and microsatellite instability predicts survival.Semantic proximity Read ↗

Integrated analysis of molecular and clinical prognostic factors in stage II/III colon cancer.Semantic proximity Read ↗

Prognostic value of K-ras mutations and allelic imbalance on chromosome 18q in patients with resected colorectal cancer.Semantic proximity Read ↗

Allelic loss of chromosome 18q and prognosis in colorectal cancer.Semantic proximity Read ↗

Association Between Recurrence of Sporadic Colorectal Cancer, High Level of Microsatellite Instability, and Loss of Heterozygosity at Chromosome 18qSemantic proximity Read ↗

Biomarkers in colorectal cancer: Current clinical utility and future perspectivesSemantic proximity Read ↗

Chromosome 18q allelic loss and prognosis in stage II and III colon cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.