Article
Allelic loss of chromosome 18q and prognosis in colorectal cancer.
The New England journal of medicine - 28 Jul 1994
Jen J, Kim H, Piantadosi S, Liu Z F, Levitt R C, Sistonen P, Kinzler K W, Vogelstein B, Hamilton S R
Abstract excerpt
BACKGROUND: Colorectal cancer occurs in approximately 150,000 people each year in the United States. Prognostic assessment influences the treatment of patients with colorectal cancer, including decisions about adjuvant therapy. We evaluated chromosome 18q allelic loss, a genetic event associated with tumor progression, as a prognostic marker for this disease. METHODS: We developed procedures to examine the status...
Topics
- Aged
- Alleles
- Base Sequence
- Biomarkers, Tumor
- Chromosome Deletion
- Chromosomes, Human, Pair 18
- Colorectal Neoplasms
- DNA Primers
- DNA, Neoplasm
- DNA, Satellite
- Female