Association of the SS genotype of the L-myc gene and loss of 18q sequences with a worse clinical prognosis in colorectal cancers.

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Article

Association of the SS genotype of the L-myc gene and loss of 18q sequences with a worse clinical prognosis in colorectal cancers.

Oncogene - 1 Apr 1994

Young J, Buttenshaw R, Butterworth L, Ward M, Searle J, Leggett B, Chenevix-Trench G

Abstract excerpt

L-myc is a nuclear oncogene which is sometimes activated late in tumourigenesis. Digestion of DNA with EcoRI reveals a simple restriction fragment length polymorphism (RFLP) located in the second intron of L-myc, with allele sizes 10 kb (L-allele) and 6.6 kb (S-allele). Some studies have suggeste...

Topics

Adult
Aged
Alleles
Chromosome Deletion
Colorectal Neoplasms
Female
Gene Frequency
Genes, myc
Humans
Male
Middle Aged
Neoplasm Metastasis
Point Mutation
Polymorphism, Restriction Fragment Length
Prognosis

Source

Open in PubMed

Identifiers

PMID: 7907781

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7907781-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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