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Article

Engineered RNase P ribozymes inhibit gene expression and growth of cytomegalovirus by increasing rate of cleavage and substrate binding.

Journal of molecular biology - 25 Jan 2002

Trang Phong, Hsu Amy, Zhou Tianhong, Lee Jarone, Kilani Ahmed F, Nepomuceno Edward, Liu Fenyong

Abstract excerpt

We have previously employed an in vitro (genetic) selection procedure to select RNase P ribozyme variants for their activity in cleaving a mRNA substrate from a pool of ribozymes containing randomized sequences. In this study, one of the variants was used to target the overlapping region of the mRNAs encoding the major transcription regulatory proteins, IE1 and IE2, of human cytomegalovirus (HCMV). The ribozyme...

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Share to Cytomegalovirus
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Viral

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Source

Identifiers

PMID: 11812131
DOI: 10.1006/jmbi.2001.5291

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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