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Article

In vitro selection of RNase P RNA reveals optimized catalytic activity in a highly conserved structural domain.

RNA (New York, N.Y.) - 1 Dec 1996

Frank D N, Ellington A E, Pace N R

Abstract excerpt

In vitro selection techniques are useful means of dissecting the functions of both natural and artificial ribozymes. Using a self-cleaving conjugate containing the Escherichia coli ribonuclease P RNA and its substrate, pre-tRNA (Frank DN, Harris ME, Pace NR, 1994, Biochemistry 33:10800-10808), we have devised a method to select for catalytically active variants of the RNase P ribozyme. A selection experiment was...

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PMID: 8972768
PMCID: PMC1369446

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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