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Article

Reduction of natural adenovirus tropism to mouse liver by fiber-shaft exchange in combination with both CAR- and alphav integrin-binding ablation.

Journal of virology - 1 Dec 2003

Koizumi Naoya, Mizuguchi Hiroyuki, Sakurai Fuminori, Yamaguchi Teruhide, Watanabe Yoshiteru, Hayakawa Takao

Abstract excerpt

The primary receptor, the coxsackievirus and adenovirus receptor (CAR), and the secondary receptor, alphav integrins, are the tropism determinants of adenovirus (Ad) type 5. Inhibition of the interaction of both the fiber with CAR and the penton base with the alphav integrin appears to be crucial to the development of targeted Ad vectors, which specifically transduce a given cell population. In this study, we...

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Identifiers

PMID: 14645563
DOI: 10.1128/jvi.77.24.13062-13072.2003
PMCID: PMC296053

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Reduction of natural adenovirus tropism to mouse liver by fiber-shaft exchange in combination with both CAR- and alphav integrin-binding ablation.PMID 14645563Read ↗

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