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Article

Genetically Targeted Adenovirus Vector Directed to CD40-Expressing Cells

13 Oct 2003

Abstract excerpt

The success of gene therapy depends on the specificity of transgene delivery by therapeutic vectors. The present study describes the use of an adenovirus (Ad) fiber replacement strategy for genetic targeting of the virus to human CD40, which is expressed by a variety of diseased tissues. The tropism of the virus was modified by the incorporation into its capsid of a protein chimera comprising structural domains...

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PMID: 14557622
DOI: 10.1128/jvi.77.21.11367-11377.2003

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