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Article

Evolution of germ-line signals that regulate growth and aging in nematodes.

Proceedings of the National Academy of Sciences of the United States of America - 22 Jan 2002

Patel Mavji N, Knight Christopher G, Karageorgi Constantina, Leroi Armand M

Abstract excerpt

We show that a signal from the germ line represses growth in the nematode Caenorhabditis elegans. Laser-microbeam ablation of cells that give rise to the germ line causes adults to become giant. Ablation of these cells in self-sterile mutant worms also causes gigantism, suggesting that the germ line represses growth because it is the source of a growth-antagonizing signal rather than because of a sink of...

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Identifiers

PMID: 11805331
DOI: 10.1073/pnas.012511099
PMCID: PMC117380

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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