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Article

cGMP and a germ-line signal control body size in C. elegans through cGMP-dependent protein kinase EGL-4.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Sept 2004

Nakano Yoshiya, Nagamatsu Yasuko, Ohshima Yasumi

Abstract excerpt

Mechanisms involved in the control of body size are largely unknown. In the nematode C. elegans, several small body size mutants were isolated, and the responsible genes were reported to encode putative components of a TGFbeta signalling pathway. Recently, mutants in the egl-4 gene encoding cGMP-dependent protein kinases were found to have a larger body size, and it was suggested that EGL-4 down-regulates the...

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PMID: 15330854
DOI: 10.1111/j.1365-2443.2004.00771.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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