The microRNA pathway controls germ cell proliferation and differentiation in C. elegans.

doi:10.1038/cr.2012.31

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Article

The microRNA pathway controls germ cell proliferation and differentiation in C. elegans.

Cell research - 1 Jun 2012

Bukhari Syed Irfan Ahmad, Vasquez-Rifo Alejandro, Gagné Dominic, Paquet Eric R, Zetka Monique, Robert Claude, Masson Jean-Yves, Simard Martin J

Abstract excerpt

The discovery of the miRNA pathway revealed a new layer of molecular control of biological processes. To uncover new functions of this gene regulatory pathway, we undertook the characterization of the two miRNA-specific Argonaute proteins in Caenorhabditis elegans, ALG-1 and ALG-2. We first observed that the loss-of-function of alg-1 and alg-2 genes resulted in reduced progeny number. An extensive analysis of the...

Topics

Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Cell Differentiation
Cell Proliferation
Germ Cells
Gonads
Meiosis
MicroRNAs
Mitosis
Mutation
Oocytes
Phenotype
RNA Interference
RNA-Binding Proteins

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Identifiers

PMID: 22370633
DOI: 10.1038/cr.2012.31
PMCID: PMC3367518

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