Article
SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP).
The Journal of biological chemistry - 5 Apr 2002
Vucic Domagoj, Deshayes Kurt, Ackerly Heidi, Pisabarro Maria Teresa, Kadkhodayan Saloumeh, Fairbrother Wayne J, Dixit Vishva M
Abstract excerpt
Inhibitors of apoptosis (IAPs) physically interact with a variety of pro-apoptotic proteins and inhibit apoptosis induced by diverse stimuli. X-linked IAP (X-IAP) is a prototype IAP family member that inhibits several caspases, the effector proteases of apoptosis. The inhibitory activity of X-IAP is regulated by SMAC, a protein that is processed to its active form upon receipt of a death stimulus. Cleaved SMAC...
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