Article
CLL cells are resistant to smac mimetics because of an inability to form a ripoptosome complex.
Cell death & disease - 29 Aug 2013
Maas C, Tromp J M, van Laar J, Thijssen R, Elias J A, Malara A, Krippner-Heidenreich A, Silke J, van Oers M Hj, Eldering E
Abstract excerpt
In the lymph node (LN) environment, chronic lymphocytic leukemia (CLL) cells display increased NF-κB activity compared with peripheral blood CLL cells, which contributes to chemoresistance. Antagonists of cellular inhibitor of apoptosis proteins (cIAPs) can induce apoptosis in various cancer cells in a tumor necrosis factor-α (TNFα)-dependent manner and are in preclinical development. Smac-mimetics promote...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.