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Article

Smac/DIABLO selectively reduces the levels of c-IAP1 and c-IAP2 but not that of XIAP and livin in HeLa cells.

The Journal of biological chemistry - 23 Apr 2004

Yang Qi-Heng, Du Chunying

Abstract excerpt

The inhibitor of apoptosis (IAP) proteins bind and inhibit caspases via their baculovirus IAP repeat domains. Some of these IAPs are capable of ubiquitinating themselves and their interacting proteins through the ubiquitin-protein isopeptide ligase activity of their RING domain. The Drosophila IAP antagonists Reaper, Hid, and Grim can accelerate the degradation of Drosophila IAP1 and some mammalian IAPs by...

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Source

Identifiers

PMID: 14960576
DOI: 10.1074/jbc.M401253200

Genes

DIABLO
XIAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Smac/DIABLO selectively reduces the levels of c-IAP1 and c-IAP2 but not that of XIAP and livin in HeLa cells.PMID 14960576Read ↗

Unlike Diablo/smac, Grim promotes global ubiquitination and specific degradation of X chromosome-linked inhibitor of apoptosis (XIAP) and neither cause apoptosis.Semantic proximity Read ↗

Livin promotes Smac/DIABLO degradation by ubiquitin-proteasome pathway.Semantic proximity Read ↗

Targeting XIAP for Promoting Cancer Cell Death—The Story of ARTS and SMACSemantic proximity Read ↗

Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway.Semantic proximity Read ↗

The RING domain of cIAP1 mediates the degradation of RING-bearing inhibitor of apoptosis proteins by distinct pathways.Semantic proximity Read ↗

The Drosophila inhibitor of apoptosis (IAP) DIAP2 is dispensable for cell survival, required for the innate immune response to gram-negative bacterial infection, and can be negatively regulated by the reaper/hid/grim family of IAP-binding apoptosis inducers.Semantic proximity Read ↗

X-Linked Inhibitor of Apoptosis Protein â€“ A Critical Death Resistance Regulator and Therapeutic Target for Personalized Cancer TherapySemantic proximity Read ↗

Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms.Semantic proximity Read ↗

SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP).Semantic proximity Read ↗

Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function.Semantic proximity Read ↗

Drosophila BRUCE inhibits apoptosis through non-lysine ubiquitination of the IAP-antagonist REAPER.Semantic proximity Read ↗

Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim.Semantic proximity Read ↗

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