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XIAP promotes melanoma growth by inducing tumour neutrophil infiltration

19 Apr 2022

Abstract excerpt

Elevated expression of the X‐linked inhibitor of apoptosis protein (XIAP) has been frequently reported in malignant melanoma suggesting that XIAP renders apoptosis resistance and thereby supports melanoma progression. Independent of its anti‐apoptotic function, XIAP mediates cellular inflammatory signalling and promotes immunity against bacterial infection. The pro‐inflammatory function of XIAP has not yet been...

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PMID: 35437868
DOI: 10.15252/embr.202153608

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