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The Inhibitor of Apoptosis Proteins as Therapeutic Targets in Cancer

15 Oct 2007

Abstract excerpt

Apoptosis is a cell suicide process with a major role in development and homeostasis in vertebrates and invertebrates. Inhibition of apoptosis enhances the survival of cancer cells and facilitates their escape from immune surveillance and cytotoxic therapies. Among the principal molecules contributing to this phenomenon are the inhibitor of apoptosis (IAP) proteins, a family of antiapoptotic regulators that block...

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PMID: 17947460
DOI: 10.1158/1078-0432.ccr-07-0729

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