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Molecular Pathways: Targeting Death Receptors and Smac Mimetics

14 May 2014

Abstract excerpt

Inhibitor of apoptosis (IAP) proteins are overexpressed in multiple human malignancies, an event that is associated with poor prognosis and treatment resistance. Therefore, IAP proteins represent relevant targets for therapeutic intervention. Second mitochondrial activator of caspases (Smac) is a mitochondrial protein that is released into the cytosol upon the induction of programmed cell death and promotes...

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PMID: 24824309
DOI: 10.1158/1078-0432.ccr-13-2376

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