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Anti-apoptotic proteins in the autophagic world: an update on functions of XIAP, Survivin, and BRUCE

5 Feb 2020

Abstract excerpt

X-linked inhibitor of apoptosis protein (XIAP), survivin, and BRUCE are members of the inhibitor-of-apoptosis protein (IAP) family known for their inhibitory effects on caspase activity and dysregulation of these molecules has widely been shown to cause embryonic defects and to promote tumorigenesis in human. Besides the anti-apoptotic functions, recent discoveries have revealed that XIAP, survivin, and BRUCE...

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PMID: 32019552
DOI: 10.1186/s12929-020-0627-5

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