Article
Evaluation of the performance of a p53 sequencing microarray chip using 140 previously sequenced bladder tumor samples.
Clinical chemistry - 1 Oct 2000
Wikman F P, Lu M L, Thykjaer T, Olesen S H, Andersen L D, Cordon-Cardo C, Orntoft T F
Abstract excerpt
BACKGROUND: Testing for mutations of the TP53 gene in tumors is a valuable predictor for disease outcome in certain cancers, but the time and cost of conventional sequencing limit its use. The present study compares traditional sequencing with the much faster microarray sequencing on a commercially available chip and describes a method to increase the specificity of the chip. METHODS: DNA from 140 human bladder...
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