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Article

Role of c-Jun NH2-terminal kinase in G-protein-coupled receptor agonist-induced cardiac plasminogen activator inhibitor-1 expression.

Journal of molecular and cellular cardiology - 1 Apr 2005

Omura Takashi, Yoshiyama Minoru, Matsumoto Ryo, Kusuyama Takanori, Enomoto Soichiro, Nishiya Daisuke, Izumi Yasukatsu, Kim Shokei, Ichijo Hidenori, Motojima Masaru, Akioka Kaname, Iwao Hiroshi, Takeuchi Kazuhide, Yoshikawa Junichi

Abstract excerpt

Plasminogen activator inhibitor-1 (PAI-1) has been implicated as a contributing risk factor for cardiovascular disease. However, little is known about molecular mechanisms of cardiac PAI-1 gene expression. To elucidate these mechanisms, dominant negative mutants of c-Jun NH(2)-terminal kinase (JNK), p38MAPK, apoptosis signal-regulating kinase-1 (ASK-1) and c-Jun were overexpressed in rat neonatal ventricular...

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Identifiers

PMID: 15808835
DOI: 10.1016/j.yjmcc.2005.01.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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