Article
Modulation of MLC-2v gene expression by AP-1: complex regulatory role of Jun in cardiac myocytes.
Molecular and cellular biochemistry - 1 Jan 2001
Goswami S K, Shafiq S, Siddiqui M A
Abstract excerpt
Hypertrophic stimulation of cardiac myocytes results in rapid induction of a number of transcription factors, including members of the AP-1 family, which is followed by a programmed alteration in the pattern of gene expression. In the ventricular cardiocytes there is re-expression of the fetal atrial natriuretic factor (ANF) gene and upregulation of its myosin light chain-2 (MLC-2v). The mechanism(s) by which the...
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