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Article

M-CAT element mediates mechanical stretch-activated transcription of B-type natriuretic peptide via ERK activation.

Canadian journal of physiology and pharmacology - 1 Aug 2011

Koivisto Elina, Karkkola Laura, Majalahti Theresa, Aro Jani, Tokola Heikki, Kerkelä Risto, Ruskoaho Heikki

Abstract excerpt

The muscle-CAT (M-CAT) promoter element is found on promoters of most muscle-specific cardiac genes, but its role in cardiac pathology is poorly understood. Here we studied whether the M-CAT element is involved in hypertrophic process activated by mechanical stretch, and identified the intracellular pathways mediating the response. When an in vitro stretch model of cultured neonatal rat cardiomyocytes and...

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Share to Basic-Leucine Zipper Transcription Factors
Share to Hypertrophy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MAP Kinase Kinase 4

Share to MEF2 Transcription Factors

Share to Myogenic Regulatory Factors

Share to Natriuretic Peptide, Brain

Share to p38 Mitogen-Activated Protein Kinases

Share to Regulatory Elements, Transcriptional

Source

Identifiers

PMID: 21812548
DOI: 10.1139/y11-049

Genes

CAT
TEF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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M-CAT element mediates mechanical stretch-activated transcription of B-type natriuretic peptide via ERK activation.PMID 21812548Read ↗

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